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Against Egypt, against the army of Pharaohnecho king of Egypt, which was by the river Euphrates in Carchemish, which Nebuchadrezzar king of Babylon smote in the fourth year of Jehoiakim the son of Josiah king of Judah.

New Defender's Study Bible Notes

46:2 Carchemish. Carchemish, on the upper Euphrates, had once been a Hittite capital. It was here, almost immediately after this prophecy of Jeremiah, that the armies of Babylon defeated the invading Egyptians (605 B.C.), the event which inaugurated the great neo-Babylonian empire of Nebuchadnezzar.

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