New Defender's Study Bible Notes
2:3 In whom. Since Christ is the Creator and Sustainer of all things (Colossians 1:16, 17), and since His gospel is implicit in every thing created (Colossians 1:23), it follows that true science is essentially thinking God’s thoughts after Him. All the treasures of true wisdom and knowledge are stored up in Christ (Matthew 13:52), and all education should be Christ-centered.
2:3 wisdom. False wisdom (i.e., “philosophy”—see Colossians 2:8) was the device used by Satan to tempt Eve (Genesis 3:6), and false knowledge (i.e., “false science”—see I Timothy 6:20) was the corrupt fruit which brought death into the world (Genesis 2:17; 3:17-19).
2:3 knowledge. “Knowledge” is synonymous with “science,” both being translations of the Greek gnosis. “The fear of the Lord is the beginning” of both true wisdom and true knowledge (Proverbs 1:7; 9:10).