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And the LORD visited Sarah as he had said, and the LORD did unto Sarah as he had spoken.
For Sarah conceived, and bare Abraham a son in his old age, at the set time of which God had spoken to him.
And Abraham called the name of his son that was born unto him, whom Sarah bare to him, Isaac.
And Abraham was an hundred years old, when his son Isaac was born unto him.

New Defender's Study Bible Notes

21:1 as he has said. Despite their age–Abraham was one hundred and Sarah was ninety (Genesis 17:17)–God miraculously fulfilled His promise, made twenty-five years earlier (Genesis 12:4,7), to give them a son. Furthermore, the promise was fulfilled at the “time appointed” He had promised (Genesis 18:14).

21:4 eight days old. The act of circumcision was not only the sign of the Abrahamic covenant (see note on Genesis 17:11), but was also a significant contribution to health, of both husband and wife, as modern medical knowledge confirms. It is also well established that, as far as the health of the infant is concerned, the eighth day is the optimum time for performing the operation.

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