Challenging the BioLogos Claim that a Vitellogenin (Egg-Laying) Pseudogene Exists in the Human Genome | The Institute for Creation Research
 
Challenging the BioLogos Claim that a Vitellogenin (Egg-Laying) Pseudogene Exists in the Human Genome

In Answers Research Journal 8 (2015): 403-411

An evolutionary argument heavily promoted by the BioLogos organization as evidence of broadscale vertebrate macroevolution is the idea that the human genome contains the 150 base remnant of an egg-yolk related vitellogenin (vtg) gene acquired through descent from a common ancestor shared with chicken. However, research described in this report shows that the alleged vtg fragment in human is not a pseudogene remnant at all, but a functional enhancer element in the fifth intron of a “genomic address messenger” (GAM) gene. This GAM gene produces long noncoding RNAs that have been experimentally shown to selectively inhibit the translation of known target genes, a majority of which are implicated in a variety of human diseases. Messenger RNAs from this gene are also expressed in a variety of human brain tissues. The alleged 150 base vtg sequence contains a variety of highly conserved mammalian transcription factor binding domains, nucleosome depleted open-active chromatin, is hypo-methylated, associates with RNA polymerase 2 in long-range chromatin interactions, and binds the Mafk transcriptional regulator. These combinatorial data clearly show that it is a functional enhancer element in a GAM gene expressed in the human brain—strongly challenging the idea that this sequence is an egg-laying pseudogene genomic fossil.

Click here to read the full article text.

The Latest
CREATION PODCAST
The Secrets of the Cell | The Creation Podcast: Episode 29
Cells are the basic organisms of life and in some groups they are organisms. What is a cell? What goes on inside of a cell? Did all life come from a...

NEWS
Fossil Footprints Fit Flood Ice-Age Model
Anthropologists Thomas Urban (Cornell University) and Daron Duke (Far Western Anthropological Research Group) recently found preserved human footprints...

NEWS
Deep-Sea Lobster Microbiome
Research continues regarding complex and amazing microbiomes found on or within a variety of creatures.1 The microbiome is a microbial community...

NEWS
"Massively Exciting" Fossil Find
Now this is exciting: “Geologists have found the fossil of the earliest known animal predator. The 560-million-year-old specimen is the first of...

NEWS
Copulation Didn't Kill the Frogs, the Flood Did
Evolutionary scientists recently studied 168 frog fossils from central Germany, concluding that the frogs all drowned while aggressively mating. They claim...

CREATION PODCAST
What Can We Learn From Fossils? | The Creation Podcast: Episode...
Is evolution seen in the fossil record? Why are fossilized terrestrial animals found buried with marine creatures? What conditions were needed to form...

NEWS
Be Not Deceived: Spiritually Train to Overcome Secular Science...
Thorough instruction and discipline are the hallmark qualities of a strong military training program. Well-trained soldiers can think on their feet, adapt...

CREATION.LIVE PODCAST
Jurassic World: Dominion - Fun Movie, Bad Science | Creation.Live...
Covered in feathers, running faster than cars, and living in cold climates...these are just a few of the ideas introduced in Jurassic World: Dominion....

NEWS
CET Model in Plants Is Clearly Seen
Plant scientists have known for decades that plants aren’t just static entities. The half-million or more species of plants in the world display...

NEWS
Half-Billion-Year-Old Fossil Brains?
Once again, a recent and remarkable fossil discovery has been made challenging evolutionary theory. A strange arthropod (i.e. a radiodont) has been found...