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And the LORD said unto him, Therefore whosoever slayeth Cain, vengeance shall be taken on him sevenfold. And the LORD set a mark upon Cain, lest any finding him should kill him.

New Defender's Study Bible Notes

4:15 mark. The “mark” is not described. The Hebrew word oth is better rendered “sign.” Whether this sign was a physical marking on Cain’s body or a miraculous display of some sort, it was widely known for many generations (see Genesis 4:24) and did serve to inhibit any who might be inclined to slay Cain otherwise.

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