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And the angel answered and said unto her, The Holy Ghost shall come upon thee, and the power of the Highest shall overshadow thee: therefore also that holy thing which shall be born of thee shall be called the Son of God.

New Defender's Study Bible Notes

1:35 overshadow thee. This marvelous work of God can be nothing less than direct creation. Some have suggested such quasi-naturalistic hypotheses as parthenogenesis or artificial insemination, or perhaps that the Holy Spirit somehow fertilized Mary’s naturally produced egg, but such stratagems could only caricature the amazing incarnation—the entrance of the omnipotent, omnipresent, eternal God of creation into finite human flesh. We cannot comprehend the mechanics of such a miracle; we can only believe God’s Word.

1:35 holy thing. It is striking that the embryonic Jesus in Mary’s womb must be called “that holy thing”—not “the babe” or “the child” or something else. There is no human word to fit. Actually the word “thing” is not in the original—just “the holy,” or perhaps “the holy [One].”

1:35 Son of God. Thus Mary was the very first to hear the words “the Son of God” as applied to that Holy One who would enter her womb.

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