3:22 compassions fail not. Jeremiah recalled that God had promised that the people of Israel would be preserved and eventually restored (Jeremiah 31:37-40; 46:28; etc.), though all he could see at the moment was devastation.

3:23 great is thy faithfulness. God is faithful to His Word, even when we are not faithful and forget His Word. Note II Timothy 2:13.

3:24 my soul. Even when our possessions are gone, our bodies dying, and we seem utterly forsaken, we still, like Job (Job 13:15), can trust our souls to God.

3:24 will I hope. In Lamentations 3:21, Jeremiah has hope in the Lord; in Lamentations 3:24, recalling God’s daily mercies and unfailing compassions, he does hope in the Lord.