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He is despised and rejected of men; a man of sorrows, and acquainted with grief: and we hid as it were our faces from him; he was despised, and we esteemed him not.
Surely he hath borne our griefs, and carried our sorrows: yet we did esteem him stricken, smitten of God, and afflicted.
But he was wounded for our transgressions, he was bruised for our iniquities: the chastisement of our peace was upon him; and with his stripes we are healed.
All we like sheep have gone astray; we have turned every one to his own way; and the LORD hath laid on him the iniquity of us all.

New Defender's Study Bible Notes

53:3 we hid. Just as Adam and Eve tried to hide from God (Genesis 3:8), so we try to hide our rebellious ways from Christ.

53:3 esteemed him not. Literally, “we estimated Him as nothing”—the typical reaction of the world to Jesus Christ as our suffering substitute.

53:4 our griefs. “Griefs” means “sicknesses” (Matthew 8:17). All sickness and pain is ultimately the result of sin, especially the fatal sickness of death itself. By His death, all pain and sickness and death will finally be removed forever (Revelation 21:4, 5).

53:4 stricken. “Stricken” means “plagued.”

53:5 wounded. This phrase means literally, “thrust through,” as with a spear, or spikes, speaking of crucifixion.

53:5 bruised. This phrase means literally, “crushed,” as to death. Compare Genesis 3:15.

53:5 are healed. Note I Peter 2:24.

53:6 like sheep. This refers to a “flock of sheep,” speaking of corporate sin.

53:6 every one. “Every one” has been guilty also of personal sin.

53:6 hath laid on him. This means literally, “laid on with a death-dealing blow,” as He died both for the sin of the world and our individual sins (note John 1:29; Romans 5:12).

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