New Defender's Study Bible Notes
5:20 Woe. Six woes are pronounced on Judah in this section (Isaiah 5:8,11,18,20,21,22).
5:20 call evil good. Inversion of God’s standards of right and wrong characterizes times of apostasy and precedes times of divine judgment. This phenomenon is increasingly characteristic of Christendom today.
5:21 in their own eyes. It is typical of evolutionary pantheism, both ancient and modern, that men will be “professing themselves to be wise,” while becoming “fools” (Romans 1:22).
5:22 drink wine. This is one of many Scriptures that warns against strong drink.