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And Cain went out from the presence of the LORD, and dwelt in the land of Nod, on the east of Eden.

New Defender's Study Bible Notes

4:16 from the presence. Cain thus becomes the type of those “that obey not the gospel of our Lord Jesus Christ: Who shall be punished with everlasting destruction from the presence of the Lord” (II Thessalonians 1:8,9).

4:16 Nod. “Nod” means “wandering,” and so may be a figurative expression depicting Cain’s vagabond life-style. Since he built a city, however, it probably was also the name of the specific region in which he led this wandering existence.

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