Evolutionists Lay an Egg: Vitellogenin Pseudogene Debunked | The Institute for Creation Research

Evolutionists Lay an Egg: Vitellogenin Pseudogene Debunked

The grand evolutionary story claims that egg-laying creatures share a common ancestry with placental mammals. Non-mammalian vertebrates, such as birds and reptiles, lay eggs with nutritional reserves in the egg yolk to nourish the growing embryo inside. In contrast, the embryos of placental mammals are nourished through the placenta, a specialized organ attached to the uterine wall of the mother. Placental mammals are born alive and do not hatch from eggs.

The supposed transition from an egg-laying reproductive system to a placenta-based system is notoriously difficult for evolutionists to explain. In egg-laying creatures, a class of proteins called vitellogenins (vtg) plays a key role in either transporting or providing the nutritional substrate for proteins, lipids, phosphorous, and calcium in relation to formation of the egg yolk.1 It is believed that somehow during the course of evolution, the role of vtg proteins was replaced by the placental interface for nourishment during gestation and, after birth, by the mother’s lactation. Based on this idea, some evolutionists believe that mammalian genomes contain DNA remnants of their ancient egg-laying past.

One study claimed to have found genetic evidence of an ancient vtg gene in the human genome.2 Because the actual data for this discovery were questionable, the evolutionary community in general did not actively popularize the alleged finding. However, BioLogos, a religious group of evolutionary scientists and liberal Christian theologians, has been promoting the so-called egg-laying pseudogene3 discovery as evidence of evolution.4-6 Because this type of propaganda is targeted to the Christian community,7 the claim should be more thoroughly investigated.

The main piece of evidence for the vtg pseudogene is the presence of a 150-base human DNA sequence that shares a low level of similarity (62%) to a tiny portion of the chicken vitellogenin (vtg1) gene.8 However, the chicken vtg1 gene is actually quite large at 42,637 bases long, so a 150-base fragment of 62% similarity represents less than 0.4% of the original gene if the evolutionary story were true! But this miniscule amount of questionable data isn’t the only problem for the evolutionary egg-laying fable.

In a detailed research report recently published in a technical journal, I show that the alleged vtg fragment in humans is not a pseudogene remnant but rather a functional feature called an enhancer element toward the end (fifth intron) of a genomic address messenger (GAM) gene.8 This GAM gene produces long non-coding RNAs that have been experimentally shown to control the function of other genes, a majority of which have been implicated in a variety of human diseases. The RNA products from this GAM gene are also known to be expressed in a variety of human brain tissues that span from infant to adult.8

As an enhancer element, the 150-base alleged vtg sequence contains a variety of highly specialized sequences that enable the binding of specific protein machinery that controls the activity and function of the GAM gene.8 These specialized sequences are also associated with a wide variety of epigenetic marks—chemical modifications in the DNA. The specific types of biochemical data associated with these marks also tells us that this DNA feature is not only active but important to the overall three-dimensional structure and function of the GAM gene in a process called long-range chromatin interaction.8,9

Upon investigation, we see that this 150-base sequence is not an ancient egg-laying “fossil” in the human genome. It’s a functional enhancer element in a GAM gene expressed in brain tissues. Once again, when we examine the genetic data more closely, the evolutionary scoreboard shows nothing but a big zero—a “goose egg,” as the saying goes.

References

  1. Romano, M. et al. 2004. Vertebrate yolk proteins: A review. Molecular Reproduction and Development. 69 (1): 109-116.
  2. Brawand, D., W. Wahli, and H. Kaessmann. 2008. Loss of egg yolk genes in mammals and the origin of lactation and placentation. PLoS Biology. 6 (3): e63.
  3. A pseudogene is a functional gene rendered non-functional due to the accumulation of mutations.
  4. Venema, D. Signature in the Pseudogenes, Part 2. BioLogos. Posted on biologos.org May 17, 2010, accessed October 20, 2015.
  5. Venema, D. Is There “Junk” in Your Genome? Part 4. BioLogos. Posted on biologos.org on February 17, 2011, accessed October 20, 2015.
  6. Venema, D. ENCODE and “Junk DNA,” Part 2: Function: What’s in a Word? BioLogos. Posted on biologos.org on September 26, 2012, accessed October 20, 2015.
  7. Luskin, C. 2014. The new theistic evolutionists: BioLogos and the rush to embrace the “consensus.” Christian Research Journal. 37 (3): 32-41.
  8. Tomkins, J. P. 2015. Challenging the BioLogos Claim that a Vitellogenin (Egg-Laying) Pseudogene Exists in the Human Genome. Answers Research Journal. 8: 403–411.
  9. Long-range chromatin interactions refer to the three-dimensional looping of DNA associated with the proper function of a gene. They are mediated in part by enhancer elements.

* Dr. Tomkins is Research Associate at the Institute for Creation Research and received his Ph.D. in genetics from Clemson University.

 

 

Cite this article: Jeffrey P. Tomkins, Ph.D. 2016. Evolutionists Lay an Egg: Vitellogenin Pseudogene Debunked. Acts & Facts. 45 (1).

The Latest
NEWS
Giant Ants Buried in Receding Flood Rocks
Evolutionary scientists are baffled by a large ant fossil found in British Columbia, Canada. Known as Titanomyrma, this same ant had been found previously...

CREATION PODCAST
Why Do Animals Hibernate? | The Creation Podcast: Episode 45
The word hibernation is often used in reference to deep sleep, but what is it really? What kinds of creatures hibernate? How does this demonstrate the...

NEWS
Thalattosuchians—Extinct Crocodile Relatives?
The Thalattosuchia are an extinct group of marine crocodylomorphs (a group that includes the crocodiles) that allegedly transitioned from land to water...

NEWS
The Star-Nosed Mole
The star-nosed mole (Condylura cristata) is a fascinating semi-aquatic mammal found in eastern Canada and the United States. Moles (placental mammals)...

NEWS
The Hexagon: An Indication of Order and Design in Nature
In nature, noncoincidental patterns and geometry exist everywhere. But the number six appears to overshadow nature’s mathematical landscape. Whether...

NEWS
Neanderthal Crab Bake
The evolutionary science community said it perfectly in their headlines: “Proof that Neanderthals ate crabs is another 'nail in the coffin'...

CREATION PODCAST
Is There Any Truth to Dragon Legends? | The Creation Podcast:...
Dragons are considered by many to be made-up creatures in fairytales and legends, but our ancestors produced many descriptions and depictions of "dragons,"...

NEWS
Our Sun, Finely Tuned for Life on Earth
Aside from appreciating the splendor of the sun during a beautiful sunrise or sunset, many rarely consider how special, necessary, and finely tuned...

NEWS
March 2023 ICR Wallpaper
"Sing to the Lord with thanksgiving; Sing praises on the harp to our God, Who covers the heavens with clouds, Who prepares rain for the earth, Who...

ACTS & FACTS
Creation Kids: Auroras
by Lori Fausak and Susan Windsor* You’re never too young to be a creation scientist! Kids, discover fun facts about God’s creation...