Most arguments against the possibility of mutation as a mechanism for evolution revolve around two premises: that mutations are almost always harmful, and that the idea of their improving rather than harming organisms is contrary to the Second Law of Thermodynamics, which tells us that matter and energy naturally tend toward greater randomness rather than greater order and complexity.

As more and more scientists adopt the creation model, there ought to be an increasing emphasis on examining data from a creationist viewpoint and a decreasing emphasis on searching out failures of the evolution model to make true or testable predictions.