"He was in the world, and the world was made by him, and the world knew him not." (John 1:10)
This verse is surely one of the saddest, most poignant verses in all the Word of God. In the Lord Jesus Christ, our Creator/Redeemer, "we live, and move, and have our being" (Acts 17:28). The atoms of our bodies are sustained by Him (Colossians 1:17), yet multitudes ignore Him, ridicule Him, and take His name in vain. What presumption! What foolishness!
Once He even entered visibly into the world He had created so that people actually could hear His words of life and see His works of love. But they willfully refused to acknowledge Him, and then hung Him on a cross to die.
The height of irony and the depth of foolishness are reached when those whose very minds and bodies were created by Christ refuse even to admit the fact of creation. In effect, they turn Psalm 100:3 upside down and claim: "It is not he that hath made us--it is we ourselves!" Not only do modern men deny His creation, they also reject His salvation, thinking they can save themselves.
It is important to note that John 1:10 specifically refers to the refusal of the "world" to know Him as its Creator. It was made by Him, but would not acknowledge His work of creation. How then could the world ever "receive" Him as its Savior (v. 11)? Only its Creator could ever become its Savior, since no one else in all creation was both deserving and capable of such a mission.
Even more inexcusable than those who rejected Him when He was here in the world are those who reject Him today. With all the marvelous evidences of creative design in nature as revealed by modern science, plus the unanswerable evidences of His own bodily resurrection from the dead, it is wicked foolishness for modern men and women still to reject Him as their Creator and Savior. HMM