Mutation Underlies Fatal Heart Condition | The Institute for Creation Research

Mutation Underlies Fatal Heart Condition

A 15-year-long project finally bore fruit after researchers painstakingly identified a specific gene mutation that can lead to sudden heart failure in otherwise healthy-looking young people. These newly published results counter the long-standing view that mutations can somehow drive evolutionary innovation.

The gene in question, named CDH2, carries the instructions for cells to build N-cadherin. This protein binds adjacent heart muscle cells together like mortar between bricks. With faulty mortar, bricks may stack up just fine, but they can suddenly collapse in a strong wind. A similar tragedy occurs with a CDH2 mutation. This error in the instructional code produces warped N-cadherin that leaves vital heart cells with a weak attachment to one another.

Dr. Guillaume Paré from McMaster University led the genetic sequencing aspect of the project. A McMaster University news report stated that, in the absence of immediate medical aid, the mutation can sometimes "causes sudden death in a few minutes."1

Other members of the team worked with a South African family who had lost several loved ones to this mutation-caused disease. The researchers found coding errors in the same CDH2 gene from multiple families, ruling out DNA differences in other genes. With this discovery, affected but informed families can take steps toward interventions.

Meanwhile, this disease demonstrates that mutations represent DNA copying errors. These errors fit three broad categories. First, they can cause fatal diseases like sudden heart failure. Second, they can also cause non-fatal diseases. And third, the genetic redundancy, gene damage detection and repair protocols, and dynamic gene networking solutions that the Creator build into human cells ensure that the vast majority of mutations bring forth effects so slightly harmful as to be unnoticeable during just one lifetime.2

Think of most mutations as raindrops that help erode brick buildings over centuries. Raindrops can't construct brick buildings, but they do erode them. Mistakes in mortar mixtures don't improve brick buildings, they weaken them. Similarly, mutations never draft or upgrade genetic blueprints for protein construction.3 At least, no scientist has yet published a single example of that type of occurance.4

Mutations to CDH2 illustrate the classic question: How can information be built up by mutations that consistently lose it?5 The discovery of a mutation behind this sad heart disease offers one more reason why errors in pre-existing coding instructions represent the least likely candidates imaginable to generate life-giving information.

References

  1. Gene found to cause sudden death in young people. McMaster University news release. Posted on mcmaster.ca March 9, 2017, accessed March 17, 2017.
  2. Thomas, B. 2012. Human Mutation Clock Confirms Creation. Acts & Facts. 41 (11): 17.
  3. Thomas, B. Powerhouse of Scientists Refute Evolution, Part Two. Creation Science Update. Posted on ICR.org June 16, 2014, accessed March 16, 2017. 
  4. Behe, M. J. 2010. Experimental evolution, loss-of-function mutations, and "the first rule of adaptive evolution." Quarterly Review of Biology. 85 (4): 419-445.
  5. Or, how can mutations build precise genetic information faster than mutations are known to lose it?

*Mr. Thomas is Science Writer at the Institute for Creation Research.

Article posted on April 3, 2017.

The Latest
CREATION.LIVE PODCAST
Forged in Faith: The Hard Work of Making Disciples | Creation.Live...
Jesus commanded that we make disciples, but what does that mean in this modern world? Has the church gone soft?   Hosts Trey and...

NEWS
Algal Microfossils Show No Evolution
Creation scientists maintain that if something is living, then it’s automatically complex. This applies to organisms ranging from a single bacterium...

CREATION PODCAST
Rapid Erosion Devastates Deep Time! | The Creation Podcast: Episode...
Erosion takes place slowly, over millions of years, right? That's what mainstream science tells us anyway. Or, does erosion happen far more...

NEWS
Flood Solves Land and Marine Mixing Near the Andes
A recent article published by Hakai Magazine claims to reveal secrets of an ancient inland sea that existed east of the Andes Mountains,1...

NEWS
T. rex Out of Nowhere
As one of the largest predators ever at 45 feet long, it’s no wonder school children are enthralled with Tyrannosaurus rex. But where did the...

NEWS
February 2024 ICR Wallpaper
"Beloved, if God so loved us, we also ought to love one another." (1 John 4:11 NKJV) ICR February 2024 wallpaper is now available...

NEWS
Evolutionist and ICR Research Both Attempting to Explain Fossil...
Recent evolutionary research is attempting to provide an explanation for why some animals became smaller over time. Or equivalently, it is attempting...

NEWS
Animal Features Did Not Evolve
There’s no doubt that animals in God’s creation have iconic features. The question is, did these features evolve or were they created that...

CREATION PODCAST
Taking a Closer Look at Uniquely Human Eyes | The Creation Podcast:...
While we might take them for granted, our eyes are incredibly complex organs. How do they work? Is it possible for eyes to have evolved over long...

NEWS
The Conserved Complexity of Eye Cell Types
The late leading evolutionary biologist, Ernst Mayr, said the eye appeared at least 40 times “during the evolution of animal diversity.”1...