Complex Metabolic Process in Fish Startles Evolutionists | The Institute for Creation Research
Complex Metabolic Process in Fish Startles Evolutionists
A complex metabolic process called Chaperone-Mediated-Autophagy (CMA) was thought to be a recent evolutionary development in land vertebrates as it was only previously documented in mammals and birds. Now it has been found to be fully operational in fish—once again demonstrating that a lack of human knowledge is not evidence for evolution.1

Autophagy is an amazingly complex and ingenious process in which cells are able to degrade and recycle their own damaged or dysfunctional components. It not only allows for the efficient recycling of important molecules and biochemical structures, but produces a stable equilibrium between interdependent cellular elements and physiological processes. In other words, it’s essential to life.

Mutations in the genes that code for the proteins that control the autophagy processes typically result in disease and health problems. There are actually a variety of biochemical pathways for autophagy in the cell. One of these is called Chaperone-Mediated-Autophagy (CMA) and it contributes to the degradation and recycling of a wide range of proteins and is essential in the regulation of various cell functions, including gene activity, DNA repair, cell cycle regulation, and cellular metabolism. Mutations in genes regulating CMA have been linked to a number of human diseases, including neurodegenerative disorders, various types of cancer, metabolic problems, and immune system dysfunction.

Up until recently, scientists have believed that CMA was a recent evolutionary development that first appeared in land vertebrates, namely mammals and birds. This was due to researchers’ prior inability to locate genes associated with CMA in fish. And quite conveniently, this scenario fit well with the evolutionary claim that fish are the primitive ancestors of land vertebrates and would thus be supposedly lacking more advanced cellular systems.

More specifically, the evolutionists were basing their assumptions on the absence of any identifiable LAMP2A gene in fish. This gene encodes a necessary protein for CMA activity as found in mammals and birds. However, in 2018, researchers finally stumbled across some evidence for the gene in a fish database called Phylofish.2 They discovered that several fish species had active genes that were fairly similar to the mammalian version of LAMP2A. This finding startled them because it suggested that CMA was active in fish much earlier in vertebrate evolution than initially thought.

In this new study, these same researchers have bolstered the evidence for LAMP2A and CMA activity in fish.1 By using specialized fluorescent biomolecule reporting technology that can be visualized with a light microscope, they confirmed the existence of a CMA pathway in cells of the fish medaka (Oryzias latipes) as had been done previously in mammalian cells. They also mutated the LAMP2A gene in fish, which resulted in severe dysfunction in carbohydrate and fat metabolism—a result previously demonstrated in mice. Taken together, this new study shows that CMA also occurs in fish where it performs an essential role in cell metabolic regulation.

This new research also shows that the diverse complexity of autophagy systems was present in vertebrate systems fully formed and functional with no evolutionary precursors. While these results confound evolutionary ideas and presuppositions about life steadily progressing from simple to complex, the data fits perfectly with the creation model of plant and animal origins where complex cellular systems have been present from the very beginning and can be found at all levels of life.

References
1. Lescat, L. et al. 2020. Chaperone-Mediated Autophagy in the light of evolution: insight from fish. Molecular Biology and Evolution. DOI10.1093/molbev/msaa127.
2. Lescat, L. et al. 2018. CMA restricted to mammals and birds: myth or reality? Autophagy. 14 (7): 1267‑1270.

*Dr. Tomkins is Life Sciences Director at the Institute for Creation Research and earned his doctorate in genetics from Clemson University.
The Latest
NEWS
Evolutionists Struggle to Explain Canadian-Australian Connection
A new species of a split-footed lacewing was recently unearthed in British Columbia, Canada, creating a bit of controversy among secular paleontologists.1...

NEWS
Surveillance Tracing: Red Pandas in Himalayan Nepal
It’s tough to be a red panda in this fallen world, especially after the global Flood. Conservationists are satellite tracking red pandas in...

NEWS
Maine Lobsters Make International News
The life of a Maine lobster is mostly a matter of crawling around on muddy continental shelf seafloors, not far from a coastline. Benthic scavenging is...

NEWS
Should We Grouse About Not Seeing Grouse?
A recent report in Chesapeake Bay Journal laments the decline in ruffed grouse populations in the Chesapeake watershed region of its natural range. Ruffed...

NEWS
Meet Dr. G: Roller Skating, Evangelism, and a Changed Life
Have you heard the news? ICR’s Board of Trustees recently appointed Dr. Randy Guliuzza to be ICR’s new President & Chief Operating Officer....

NEWS
Honeybees: How Sweet It Is, Again
After some scary population downturns and scarier rumors of bee populations crashing, honeybees are making a comeback, populationally speaking.1,2...

NEWS
Dolphins Learn Tricks from Peers to Catch Fish
Dolphins—like other cetaceans such as whales, wholphins, and porpoises—are highly intelligent marine mammals, capable of astonishing feats....

NEWS
Liberty and the Word of God
“And I will walk at liberty: for I seek thy precepts” (Psalm 119:45). July 4th is called Independence Day here in our country because on...

NEWS
Wandering Albatross: Wide Wings on the Winds
Wandering albatrosses have the largest wingspan of any living bird, so they live much of life soaring above the oceans. With their wings—and a lot...

NEWS
Inside July 2020 Acts & Facts
Where can we find hope during times of waiting? How has ICR reached a new global audience? How does evolution conflict with the Bible's teaching...