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And the seventh angel poured out his vial into the air; and there came a great voice out of the temple of heaven, from the throne, saying, It is done.

New Defender's Study Bible Notes

16:16 Armageddon. “Armageddon” is, more precisely, “Har-Megiddo,” or “Mount of Megiddo.” Megiddo itself is a small and very ancient town about sixty miles north of Jerusalem, overlooking the plain of Megiddo on the west and the plain of Esdraelon (or valley of Jezreel) on the northeast. This vast plains area is the obvious location for large armies to bivouac in preparation for an attack on Jerusalem. By the time all the armies arrive there, however, even this large plain cannot contain them all. Many must be deployed down the Jordan valley and the valley of Jehoshaphat, near Jerusalem, past the Dead Sea into Idumea and even beyond Bozrah (see notes on Revelation 14:20). They will come from all over the world by any means of transportation they can obtain. With the world’s resources already severely depleted by the plagues, and oil probably in short supply in most nations, many will have to commandeer horses or camels or donkeys to come. But come they will, in multitudes.

16:17 seventh angel. The last poured-out vial of wrath issues in the final destruction of Babylon, both religious Babylon (Revelation 17) and political Babylon (Revelation 18), capitals of the domains of the false prophet and the beast, respectively.

16:18 so mighty an earthquake. There have been many devastating earthquakes on earth, ever since the eruption of the primeval subterranean water channels that initiated the great Flood and the tectonic uplifts that terminated it (Genesis 7:11; Psalm 104:6-9). The global earthquake at the judgment of the sixth seal (Revelation 6:12-17) had been so severe that “every mountain and island were moved out of their places.” This earthquake, however, is far worse—so bad, in fact, that “every island fled away, and the mountains were not found” (Revelation 16:20).

16:19 cities of the nations. The destructive force of this global earthquake will be so great that, like Jericho at the shout of Joshua’s army, “the cities of the nations fell,” meaning that all their structures collapsed. Jerusalem, however, will not fall, but God will divide it through the midst of the Mount of Olives (the Valley of Kidron already divides it into two parts—note Zechariah 14:4,8) when the Lord returns to stand on the Mount of Olives. Other Old Testament prophets also foresaw this mighty earthquake (e.g., Haggai 2:6-7; Isaiah 24:17-21; Joel 3:16).

16:19 Babylon. The destruction of Babylon had also been noted in Revelation 14:8, but this particular theme is so important that John will interrupt the chronological account at this point in order to devote two entire chapters (Revelation 17 and 18) to it.

16:20 mountains were not found. The smoothing of the topography of the world in this way is in preparation for the millennial earth as well, fulfilling Isaiah 40:4-5.

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