New Defender's Study Bible Notes
3:15 enmity between thee. This verse is famous as the Protevangel (“first gospel”). The Curse was directed immediately towards the Serpent, but its real thrust was against the evil spirit possessing its body, “that old serpent, called the Devil” (Revelation 12:9). Satan may have assumed he had now won the allegiance of the woman and all her descendants, but God told him there would be enmity between him and the woman.
3:15 her seed. The “seed of the woman” can only be an allusion to a future descendant of Eve who would have no human father. Biologically, a woman produces no seed, and except in this case Biblical usage always speaks only of the seed of men. This promised Seed would, therefore, have to be miraculously implanted in the womb. In this way, He would not inherit the sin nature which would disqualify every son of Adam from becoming a Savior from sin. This prophecy thus clearly anticipates the future virgin birth of Christ.
3:15 bruise thy head. Satan will inflict a painful wound on the woman’s Seed, but Christ in turn will inflict a mortal wound on the Serpent, crushing his head. This prophecy was fulfilled in the first instance at the cross, but will culminate when the triumphant Christ casts Satan into the lake of fire (Revelation 20:10).
3:15 bruise his heel. This primeval prophecy made such a profound impression on Adam’s descendants that it was incorporated, with varying degrees of distortion and embellishment, in all the legends, mythologies and astrologies of the ancients, filled as they are with tales of mighty heroes engaged in life-and-death struggles with dragons and other monsters. Mankind, from the earliest ages, has recorded its hope that someday a Savior would come who would destroy the devil and reconcile man to God.