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Now the LORD had said unto Abram, Get thee out of thy country, and from thy kindred, and from thy father's house, unto a land that I will show thee:
And I will make of thee a great nation, and I will bless thee, and make thy name great; and thou shalt be a blessing:
And I will bless them that bless thee, and curse him that curseth thee: and in thee shall all families of the earth be blessed.

New Defender's Study Bible Notes

12:1 out of thy country. The call of Abram marks a critical turning point in history. Heretofore God’s covenant with mankind (Genesis 9:8-17) applied to all men alike. With the confusion of tongues at Babel, distinct nations necessarily began to develop. Though the Noahic covenant is everlasting, it was now necessary for this to be supplemented (not replaced) by a special relation with a particular nation through which the promised Seed of the Woman (Genesis 3:15) would eventually enter the human race to redeem lost mankind.

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