14:6 Lystra and Derbe. Paul’s experiences in the interior regions of what is now Turkey were typical of most of his missionary forays. Perga was in the Roman coastal province of Pamphylia, Antioch and Iconium in the interior highlands of Pisidia and Phrygia, respectively. Both were part of the large province of Galatia. Lystra and Derbe were in Lycaonia, also a territory of Galatia. Paul and his associates almost invariably would first go to the local synagogues, where they would encounter a congregation of both Jews and God-fearing Gentiles. Many would respond to the gospel, especially among the Gentiles. This would open the door to preach also to the pagan Gentiles, and this in turn would stimulate both the unresponsive Jews and the anti-creationist pagan Gentiles to organize strong opposition to their preaching.
14:12 Mercurius. These names in the original are “Zeus” and “Hermes,” which were the same “gods” to the Greeks as Jupiter and Mercury to the Romans. There was a local legend in the region that these two gods had once appeared there as men and brought blessing. Paul’s miraculous healing of the life-long crippled man encouraged the Lystron pagans to hope the gods had returned.
14:15 these vanities. “Vanities” refers to their worship of idols, representing mere personifications of natural forces as well as demonic spirits. It is vain to attribute true creative power, such as just evidenced in the instantaneous creation of perfect new legs for the hopeless crippled man to anything other than God. Only the true Creator, or those who call on Him and speak in His name, could do such things.
14:15 living God. When Paul and Barnabas preached in the synagogues, they could begin on the premise that their hearers already believed in God, in creation of all things by God, and in the authority of the Scriptures. On this foundation, they could then preach Christ and the resurrection. When they preached to a completely pagan crowd, however, as here at Lystra and later at Athens (Acts 17:15-34), they had to begin with the evidence for one Creator God, as opposed to the popular religions which were centered either on atheism or pantheism and manifested popularly as polytheism. All of these believed in the eternity of the universe and in some form of universal evolutionism, just as most unbelievers do today.
14:16 their own ways. God was not unconcerned with this pagan ignorance, but was patient. As Paul later told the Athenians, “God winked at” it for a time (Acts 17:30). The pagans did have ample evidence, in both creation and conscience, of the true God (Romans 1:20; 2:15), as well as the witness from the Jews in their midst, so they were “without excuse” if they did not acknowledge Him. In fact many had, indeed, already come to “fear God” and listen to His Word in the synagogues (Acts 13:16,26,42), even though they had been reluctant to become proselytes to the full Jewish religion. It was such as these latter who most readily responded to the gospel of Christ when they finally heard it.

