The "Eve" Mitochondrial Consensus Sequence

Download PDFDownload The "Eve" Mitochondrial Consensus Sequence PDF

by Robert W. Carter, Dan Criswell, and John Sanford

In A. A. Snelling (Ed.) (2008). Proceedings of the Sixth International Conference on Creationism (pp. 111–116). Pittsburgh, PA: Creation Science Fellowship and Dallas, TX: Institute for Creation Research.


We have calculated the consensus sequence for human mitochondrial DNA using over 800 available sequences. Analysis of this consensus reveals an unexpected lack of diversity within human mtDNA worldwide. Not only is more than 83% of the mitochondrial genome invariant, but in over 99% of the variable positions, the majority allele was found in at least 90% of the individuals. In the remaining 0.22% of the 16,569 positions, which we conservatively refer to as “ambiguous,” every one could be reliably assigned to either a purine or pyrimidine ancestral state. There was only one position where the most common allele had an allele frequency of less than 50%, but this has been shown to be a mutational hot spot. On average, the individuals in our dataset differed from the Eve consensus by 21.6 nucleotides. Sequences derived from sub-Saharan Africa were considerably more divergent than average. Given the high mutation rate within mitochondria and the large geographic separation among the individuals within our dataset, we did not expect to find the original human mitochondrial sequence to be so well preserved within modern populations. With the exception of a very few ambiguous nucleotides, the consensus sequence clearly represents Eve's mitochondrial DNA sequence.


Mitochondrial Eve, Human evolution

For Full Text

Please see the Download PDF link above for the entire article.

The Latest
Diamonds and the Age of the Earth
Hello, I’m Dr. Vernon Cupps, ICR Research Associate and nuclear physicist. You’ve probably heard the familiar old saying, “Diamonds...

Stellar Superflare Reminder: Our Sun Is Special
Astronomers recently detected an enormous but short-lived increase in radiation from the nearby star Proxima Centauri.1,2 This radiation burst, known as...

Famous Physicist Stephen Hawking Dies at 76
Well-known physicist and atheist Stephen Hawking died at age 76 on March 14, 2018. He uniquely bridged the gap between ivory-tower academia and popular...

"Selfish Gene" Metaphor Misleads Evolutionists
A recent opinion piece posted on the Chemistry World website1 notes that Richard Dawkins’ 1976 book The Selfish Gene deeply motivated a generation...

3-D Praying Mantis Vision Confounds Evolution
In the animal kingdom, many types of creatures use stereo vision to determine the distances between them and visible objects. In humans, each of our...