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And when his friends heard of it, they went out to lay hold on him: for they said, He is beside himself.

New Defender's Study Bible Notes

3:21 beside himself. Despite His wonderful works of healing, and His strong Bible-centered preaching, His enemies accused Him of being in league with Beelzebub (i.e., Satan, Mark 3:22) and His friends thought He had lost His mind. Paul also was later accused by the Roman governor Festus of being mad (Acts 26:24). If the greatest preacher and even Christ Himself were accused of such things by the world, we must expect the same if we are faithful to His teachings (John 15:20).

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