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Behold, he breaketh down, and it cannot be built again: he shutteth up a man, and there can be no opening.

New Defender's Study Bible Notes

12:14 no opening. After speaking of the creation (Job 12:7-10), Job seems to have thought of his ancestor Noah, and the great Flood. The Lord permanently “broke down” the antediluvian civilization so that it could not be “built again.” Then He “shut him in” (Genesis 7:16) the ark, the one man in that world who had obeyed God.

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