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New Defender's Study Bible Notes
2:16 seed of Abraham. Christ “took on Him the seed of Abraham” by taking up residence for nine months in the womb of Mary, who was truly of Abraham’s seed. However, the inherent sin, as well as genetic defects, which had been transferred through Abraham’s seed (originally from Adam and Eve) to all his descendants, including Mary, could not have been incorporated in “that holy thing” created and placed in her body, for He must be “without blemish and without spot” in order to qualify as our Savior from sin. See notes on Romans 1:3; Luke 1:35; I Peter 1:19.