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Be it known therefore unto you, that the salvation of God is sent unto the Gentiles, and that they will hear it.

New Defender's Study Bible Notes

28:28 unto the Gentiles. Once again, Paul announced that, since the Jews had rejected the offer of salvation, it would go to the Gentiles. It seems somewhat symbolic that Paul has by this time preached the gospel all the way from Jerusalem to Rome, the greatest city in the world at that time, and that the account ends at this point. He had always gone first to the Jews, only to find again and again that the Gentiles were the ones who responded. It was said of Jesus that “He came unto His own, and His own received Him not” (John 1:11). The same had been proved true of His gospel.

28:28 they will hear. This has been a wonderfully fulfilled prophecy. The Gentiles, in practically every nation, have received the gospel gladly in substantial numbers. The Christians of the first century, beginning with the apostles, were largely Jews, but this soon changed. Ever since, it has been the Gentile churches and missionaries who have been spreading the gospel.

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