New Defender's Study Bible Notes
22:16 dogs have compassed me. It is possible that the reference to “dogs” was a euphemism for a crowd of sodomites (Deuteronomy 23:17-18).
22:16 pierced my hands. The piercing of His hands and feet is a clear reference to the nails which affixed Him to the cross (note also John 20:25-28; Zechariah 12:10; 13:6; John 19:37; Revelation 1:7).