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And the LORD visited Sarah as he had said, and the LORD did unto Sarah as he had spoken.
For Sarah conceived, and bare Abraham a son in his old age, at the set time of which God had spoken to him.
And Abraham called the name of his son that was born unto him, whom Sarah bare to him, Isaac.
And Abraham was an hundred years old, when his son Isaac was born unto him.
And Sarah said, God hath made me to laugh, so that all that hear will laugh with me.
And she said, Who would have said unto Abraham, that Sarah should have given children suck? for I have born him a son in his old age.
And the child grew, and was weaned: and Abraham made a great feast the same day that Isaac was weaned.
And Sarah saw the son of Hagar the Egyptian, which she had born unto Abraham, mocking.
Wherefore she said unto Abraham, Cast out this bondwoman and her son: for the son of this bondwoman shall not be heir with my son, even with Isaac.

New Defender's Study Bible Notes

21:1 as he has said. Despite their age–Abraham was one hundred and Sarah was ninety (Genesis 17:17)–God miraculously fulfilled His promise, made twenty-five years earlier (Genesis 12:4,7), to give them a son. Furthermore, the promise was fulfilled at the “time appointed” He had promised (Genesis 18:14).

21:4 eight days old. The act of circumcision was not only the sign of the Abrahamic covenant (see note on Genesis 17:11), but was also a significant contribution to health, of both husband and wife, as modern medical knowledge confirms. It is also well established that, as far as the health of the infant is concerned, the eighth day is the optimum time for performing the operation.

21:7 his old age. When God heals miraculously, he does it instantly and completely. Sarah’s body was so rejuvenated that although she was ninety years old, she was able both to bear a child and even to nurse him. Abraham was so “young” again that even at one hundred years of age he could later father six more sons of Keturah many years later, after Sarah’s death.

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