Designed Adaptations Challenge Evolution | The Institute for Creation Research
Designed Adaptations Challenge Evolution
It’s exciting when research with medical implications also provides insight into the mechanisms of biological adaptation. Two new studies contribute to a large body of research that not only contradicts the textbook account for the evolution of life on Earth, but also supports the explanation of engineered adaptability.

By way of background, the standard account of evolution is a two-step process that supposedly explains how adaptation and evolution happen. These steps are actually assumptions. The first is that the genetic variability needed to fuel evolution is produced through random genetic mutations within a population of creatures.

Mutations drive evolution and were assumed to occur by chance: constantly, gradually, roughly uniformly in genomes, and without regard to environmental inputs…The assumptions of purely ‘chance’ mutations that occur constantly, gradually, and uniformly in genomes have underpinned biology for almost a century….1

Randomness and lack of purpose infuse this evolutionary belief with anti-design characteristics. Any type of “directed” mutation could open the door to purposefully engineered mechanisms. Directed mutation has always been regarded as a threat to the basic “design without a Designer” thrust of evolutionary theory.2

The second step envisions that this genetic variability is somehow fractioned out in a given population through deadly struggles to survive. The physiological and anatomical traits of the population gradually become better fitted to their environment. Only a very small number of survivors go on to reproduce and pass on the so-called “fittest” genes. Thus, selectionists believe that thanks to natural selection, we have the marvelous variety of creatures we see in our world.

But increasing research demonstrates that these longstanding assumptions may be completely invalid. ICR has already reported on numerous recent studies that undermine the idea that genetic changes (still called “mutations”) happen randomly.3 Other literature reviews of adaptive mechanisms report,

These mechanisms reveal a picture of highly regulated mutagenesis, up-regulated temporally by stress responses and activated when cells/organisms are maladapted to their environments—when stressed—potentially accelerating adaptation. Mutation is also nonrandom in genomic space, with multiple simultaneous mutations falling in local clusters, which may allow concerted evolution…Molecular mechanisms of stress-inducible mutation change ideas about evolution…suggesting that regulated mutagenesis may be the rule, not the exception….1

Now research on colorectal cancer cells published in an article titled “Adaptive mutability of colorectal cancers in response to targeted therapies” by Mariangela Russo et al, at the Candiolo Cancer Institute in Italy finds further evidence of mechanisms leading to the purposeful manipulation of DNA.4

Colorectal cancer cell lines were treated with an antibody that blocks a sensor on the cell surface. This resulted in most of the cells dying, but some resistant cells survived. In the population of resistant cells, the team found that, during treatment, specific DNA repair genes and recombination genes were downregulated. But error-prone DNA polymerases increased. This increased genomic instability was repeatable and predictable throughout the experimental trials. This indicates that the genomic instability in the cancer cells is a regulated stress response that increases the likelihood of a cell evading the effects of the drug. Russo found that if drug therapy was stopped within two weeks, the DNA repair mechanisms returned to normal. However, they remained permanently changed if exposed to longer treatment regimens. The elements of the system linking the detection of the drug to the changes in regulation of DNA repair mechanisms aren’t yet fully understood.

A similar resistance to drug therapy, but by different mechanisms, was reported in a paper titled “Malaria parasites fine-tune mutations to resist drugs” by Leann Tilley and Philip J. Rosenthal in Nature.5 They describe fascinating discoveries by Jonathan Kim et al that directly imaged a microscopic transporter protein in a membrane of the parasite Plasmodium falciparum, the leading cause of malaria in some regions of Africa.

The transporter protein PfCRT is necessary to facilitate movement of at least two anti-malarial drugs. This allows them to build up or leave a structure inside P. falciparum. When the drug concentration builds up, it’s lethal to the parasite. Two specific genetic changes that result in two different single amino acid substitutions will allow one or the other drug to escape and not kill the parasite.

The research doesn’t report on whether these genetic changes are believed to be random or somehow internally regulated. What is known is that the changes consistently happen at the same site in the DNA when exposed to either of the anti-malarial drugs. Consistency of response is indicative of engineered mechanisms—not random activity. Tilley and Rosenthal conclude,

The authors propose that the distribution of surface charges in the cavity [the means of drug resistance] can be fine-tuned so that the initial binding of a drug to PfCRT, and its subsequent release for transport, is different for different drugs, thereby producing distinct effects on drug sensitivity. Taken together, Kim and colleagues’ findings show that P. falciparum is engaged in an ongoing balancing act, generating mutations that block the action of different drugs while maintaining optimal fitness of the parasite.

These “mutations” aren’t random in the genome but precisely targeted and are inconsistent with evolutionary theory. The precision of those genetic changes produces responses that are characterized as rapid and repetitive—indeed predictable—and are expected from the organism-focused, engineering-based model for adaptation we call continuous environmental tracking (CET).6 This model assumes that biological functions like adaptation are best explained by engineering principles tied to the pre-existing, internal capacity of creatures. Just as important, CET rejects selectionism and its mystical “selection events.” Anti-parasitic and cancer drugs don’t have minds that can “select” anything.

Scientific models based on engineered causes explain the phenomenon.

References
1. Fitzgerald, D. M. and S. M. Rosenberg. 2019. What is mutation? A chapter in the series: How microbes “jeopardize” the modern synthesis. PLoS Genetics. 15(4): e1007995.
2. Guliuzza, R. J. 2018. Engineered Adaptability: Adaptive Changes Are Purposeful, Not Random. Acts & Facts. 47 (6): 17-19.
3. Guliuzza, R. J. 2018 Engineered Adaptability: Adaptive Solutions Are Targeted, Not Trial-and-Error. Acts & Facts. 47 (7): 17-19.
4. Russo. M. et al. 2019. Adaptive mutability of colorectal cancers in response to targeted therapies. Posted on sciencemag.org on November 7, 2019, accessed November 26, 2019. doi:10.1126/science.aav4474, 2019.
5. Tilley, L. and P. J. Rosenthal. 2019. Malaria parasites fine-tune mutations to resist drugs. Posted on nature.com on November 27 2019, accessed December 6, 2019. doi: 10.1038/d41586-019-03587-0
6. Guliuzza, R. and P. Gaskill. 2018. Continuous environmental tracking: An engineering framework to understand adaptation and diversification. In Proceedings of the Eighth International Conference on Creationism, ed. J. H. Whitmore, 158–184.

Randy Guliuzza is ICR’s National Representative. He earned his Doctor of Medicine from the University of Minnesota, his Master of Public Health from Harvard University, and served in the U.S. Air Force as 28th Bomb Wing Flight Surgeon and Chief of Aerospace Medicine. Dr. Guliuzza is also a registered Professional Engineer.
The Latest
NEWS
Great American Outdoors Act, Signed into Law by President
In a bipartisan legislative achievement to promote better stewardship of American public lands, U.S. Senators and Representatives finalized their bill...

NEWS
Grandmothers, Eat Fish to Protect Your Brains!
This month the American Academy of Neurology published a medical science study showing that senior women can fight air pollution hazards, including brain...

NEWS
Embarrassment Continues over Evolutionary Blunder about “Junk...
Recent research from the Okinawa Institute of Science and Technology Graduate University (OIST) continues to highlight how evolutionary theory influenced...

NEWS
God’s Plan Is Best: Salmon Need Saltwater Acclimation
Once again, results are better when aquaculture imitates the natural life cycle of Atlantic salmon.1,2 In other words, the closer fish farmers...

NEWS
Inside August 2020 Acts & Facts
Have you heard about ICR’s new President and Chief Operating Officer, Dr. Randy Guliuzza? What can we learn from an old prayer? Is creation evidence...

NEWS
After 30 Years, Red Kites Soar in British Skies
Good news is always welcome. So, it’s good to learn of another conservation comeback. This time it’s the red kite happily soaring in Great...

CREATION PODCAST
Meet Dr. G
Hear the history and heart of ICR’s newly appointed President and Chief Operating Officer, Dr. Randy Guliuzza. He has served as ICR’s National...

ACTS & FACTS
'Doing Business' in Good Times and Bad
No doubt many of you, like me, have been earnestly looking for the return of the Lord Jesus Christ. He called all believers to be godly “salt”...

APOLOGETICS
Sentinels Are Needed in Perilous Times
Watch out! Dangers lurk everywhere—these are surely perilous times.1 One of the apologetics-exhorting themes in Jude’s epistle...

ACTS & FACTS
Why Don't Raindrops Bomb Butterfly Wings?
Okay, I admit most folks have probably not thought to ask this creation question. But a bigger question gets answered when we examine the fantastic...