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themselves to be wise, they became fools,
New Defender's Study Bible Notes
1:22 became fools. Those who deny the God of creation are fools (Psalm 14:1) and “without a defense” (see notes on Romans 1:20). Yet they come to such a foolish decision in the foolish belief that they are scientific in trying to explain the infinitely complex, majestic, beautiful creation without a Creator. The ancient pagans did this, with immeasurably tragic results in the history of the human race. Modern evangelicals, compromising with evolutionism and increasingly flirting with New Age pantheism, feminism and occultism, are in serious danger of starting down that same slippery slope. Compare II Timothy 3:1-13.