New Defender's Study Bible Notes
4:16 from the presence. Cain thus becomes the type of those “that obey not the gospel of our Lord Jesus Christ: Who shall be punished with everlasting destruction from the presence of the Lord” (II Thessalonians 1:8,9).
4:16 Nod. “Nod” means “wandering,” and so may be a figurative expression depicting Cain’s vagabond life-style. Since he built a city, however, it probably was also the name of the specific region in which he led this wandering existence.