10:27 they follow me. The Lord resumed His use of the sheep-and-shepherd “proverb;” evidently it had made a lasting impression on His questioners, even after so long a time (see note on John 10:22). He now stressed the permanence of this relationship (see also John 5:24).
10:28 out of my hand. Not only is eternal life a present possession, but the good Shepherd assures us that no one (“any man” is actually “anyone,” including even Satan himself) could ever take it away.