53:1 Who hath believed. Verses from Isaiah 53 are quoted at least six times in the New Testament, always indicating its fulfillment in Christ, more than seven hundred years later. This first skeptical and cynical rhetorical question is quoted in John 12:38 and Romans 10:16.
53:2 no beauty. Evidently Jesus, representing all men, was a very average looking man, with no particular beauty of either form or face. His beauty was inward, not outward. There is no description at all of his outward appearance in any of the four gospels.
53:3 we hid. Just as Adam and Eve tried to hide from God (Genesis 3:8), so we try to hide our rebellious ways from Christ.
53:3 esteemed him not. Literally, “we estimated Him as nothing”—the typical reaction of the world to Jesus Christ as our suffering substitute.