4:25 Seth. “Seth” means “appointed” or “substitute.” Contrast Eve’s attitude of thankfulness and trust with Lamech’s attitude (in Genesis 4:24) of vengeance and pride.
4:26 Enos. “Enos” means “mortal frailty.” It is interesting that Eve gave the name to her son, while Seth gave the name to his son. This probably suggests that both husband and wife normally consulted with one another in deciding on appropriate names for their children.
4:26 call upon the name. To “call upon the name of the LORD” normally implies a definite action of prayer and worship. It was evidently at this time that godly men and women first initiated formal public services of sacrifice, worship and prayer, replacing the earlier practice of meeting personally with God, as Cain and Abel had done. The practice of individual prayer is also intimated, implying that God’s personal presence was no longer regularly available. In any case, an act of faith is implied. In later times, “calling upon the name of the LORD” was accompanied by the building of an altar and the offering of a sacrifice (Genesis 12:8; 26:25; etc.). Since Christ’s sacrifice on Calvary, however, men need only call in faith on the name of the Lord Jesus Christ. “For whosoever shall call upon the name of the Lord shall be saved” (Romans 10:13).
4:26 the LORD. The name of the self-existing, redeeming Lord, Jehovah. There is no contradiction with Exodus 6:3, especially if the statement there is punctuated with a question mark: “But by my name JEHOVAH was I not known to them?” The obvious answer to this rhetorical question is yes.