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And he said, What hast thou done? the voice of thy brother's blood crieth unto me from the ground.

New Defender's Study Bible Notes

4:10 thy brother’s blood. This first mention of “blood” in Scripture prefigures the innocent blood of Christ, which “speaketh better things than that of Abel” (Hebrews 12:24). The voice of Abel’s blood cried for vengeance (compare Revelation 5:9, 10), but the blood of Christ speaks of cleansing and forgiveness (I John 1:7; Ephesians 1:7).

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