3:10 hid myself. The shame associated with nudity is no artificial inhibition of civilization, but has its source in this primeval awareness of sin. It is only lost when consciences are so hardened as to lose sensitivity to sin. Clothing is even worn in heaven (Revelation 1:13; 19:14).
3:11 Hast thou eaten. God’s questions were not to obtain information, but to encourage Adam and Eve to confess their sin. Instead of repentance, however, they responded by feeble attempts at self-justification, each blaming someone else. In this, they behaved like most of their descendants.
3:14 cursed above all cattle. God’s Curse fell first on the Serpent, representing man’s great enemy, the devil, as a perpetual reminder to man of his fall. All other animals were also placed under the Curse, as part of man’s dominion, but the Serpent was cursed above all others, becoming a universal object of dread and loathing. Whatever may have been its original posture, it would henceforth glide on its belly, eating its prey directly off the ground, and covered with the dust of the earth.
3:15 enmity between thee. This verse is famous as the Protevangel (“first gospel”). The Curse was directed immediately towards the Serpent, but its real thrust was against the evil spirit possessing its body, “that old serpent, called the Devil” (Revelation 12:9). Satan may have assumed he had now won the allegiance of the woman and all her descendants, but God told him there would be enmity between him and the woman.
3:15 her seed. The “seed of the woman” can only be an allusion to a future descendant of Eve who would have no human father. Biologically, a woman produces no seed, and except in this case Biblical usage always speaks only of the seed of men. This promised Seed would, therefore, have to be miraculously implanted in the womb. In this way, He would not inherit the sin nature which would disqualify every son of Adam from becoming a Savior from sin. This prophecy thus clearly anticipates the future virgin birth of Christ.

