5:22 Wives, submit yourselves. The instructions concerning the proper relations between husbands and wives—the wife submitting to her husband, the husband loving his wife with deeply sacrificial love—found in Ephesians 5:22-33 should be understood as included in the exhortation to be filled with the Spirit (Ephesians 5:18). They follow both from the original created purpose for men and women (Ephesians 5:30-31) and the relation between Christ and the church (Ephesians 5:25-27).
5:26 by the word. Sanctification and cleansing of “the church”—which certainly must include individual members—is accomplished through the Word. Note also John 17:17.
5:27 glorious church. There is no spotless church in existence today, but when Christ returns, “we shall be like Him” (I John 3:2), and shall all be in “the general assembly and church of the firstborn;” with “the spirits of just men made perfect” (Hebrews 12:23).