The "Eve" Mitochondrial Consensus Sequence

Download PDFDownload The "Eve" Mitochondrial Consensus Sequence PDF

by Robert W. Carter, Dan Criswell, and John Sanford

In A. A. Snelling (Ed.) (2008). Proceedings of the Sixth International Conference on Creationism (pp. 111–116). Pittsburgh, PA: Creation Science Fellowship and Dallas, TX: Institute for Creation Research.

Abstract

We have calculated the consensus sequence for human mitochondrial DNA using over 800 available sequences. Analysis of this consensus reveals an unexpected lack of diversity within human mtDNA worldwide. Not only is more than 83% of the mitochondrial genome invariant, but in over 99% of the variable positions, the majority allele was found in at least 90% of the individuals. In the remaining 0.22% of the 16,569 positions, which we conservatively refer to as “ambiguous,” every one could be reliably assigned to either a purine or pyrimidine ancestral state. There was only one position where the most common allele had an allele frequency of less than 50%, but this has been shown to be a mutational hot spot. On average, the individuals in our dataset differed from the Eve consensus by 21.6 nucleotides. Sequences derived from sub-Saharan Africa were considerably more divergent than average. Given the high mutation rate within mitochondria and the large geographic separation among the individuals within our dataset, we did not expect to find the original human mitochondrial sequence to be so well preserved within modern populations. With the exception of a very few ambiguous nucleotides, the consensus sequence clearly represents Eve's mitochondrial DNA sequence.

Keywords

Mitochondrial Eve, Human evolution

For Full Text

Please see the Download PDF link above for the entire article.

The Latest
TESTIMONIALS
One-of-a-Kind Exhibits
Hi, I’m Dr. Tim Clarey, the geologist at ICR. I’m excited to showcase our cutting-edge research in the ICR Discovery Center. The center’s...

NEWS
What's All the Flap About?
In the last few decades, there has been a lot of discussion by prominent paleontologists who imply that dinosaurs and birds are closely related. Many...

NEWS
Nearby Galaxy Has Almost No Dark Matter
A team of astronomers recently concluded that a nearby spheroidal galaxy, designated as NGC1052-DF2, contains very little, if any, dark matter.1,2 Since...

TESTIMONIALS
Building His Kingdom
Hello, my name is Andrew Infinger, and I work in ICR’s distribution center. As a full-time student and employee, I don’t have much time...

NEWS
Homo naledi had Lucy-Like Hips
Hips can reveal many things about fossilized organisms, especially when it comes to mammals. They can indicate the difference between species and even...